Duloxetine Gastro-Resistant Tablets IP 40 mg are prescription medications used to treat major depressive disorder, generalized anxiety disorder, and various forms of chronic pain, including diabetic neuropathy, fibromyalgia, and musculoskeletal pain. As a serotonin-norepinephrine reuptake inhibitor (SNRI), duloxetine helps increase levels of these neurotransmitters in the brain to improve mood, reduce anxiety, and manage pain more effectively. The gastro-resistant coating ensures the tablet passes through the stomach without breaking down, helping to minimize irritation and enhance absorption in the intestines.