Topiramate Tablets IP

Topiramate Tablets IP are anticonvulsant medications used to treat epilepsy and to prevent migraines. As a broad-spectrum antiepileptic, topiramate works by calming overactive nerve activity in the brain through multiple actions, including blocking sodium channels, enhancing GABA activity, and inhibiting excitatory neurotransmitters. It is commonly prescribed for partial-onset seizures, generalized tonic-clonic seizures, Lennox-Gastaut syndrome, and as a preventive treatment for migraine headaches.

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Description

Topiramate Tablets IP are widely used antiepileptic medications that help manage various types of seizures and prevent migraine headaches. The drug works by stabilizing nerve activity in the brain through multiple mechanisms. It is typically started at a low dose and gradually increased to reduce side effects.

Mechanism of Action:

Topiramate has a broad-spectrum antiepileptic mechanism. It works by:

  • Blocking voltage-dependent sodium channels, stabilizing neuronal membranes
  • Enhancing GABA activity (inhibitory neurotransmitter)
  • Inhibiting AMPA/kainate receptors (glutamate excitatory pathways)
  • Inhibiting carbonic anhydrase (weak effect)

These combined actions reduce neuronal excitability, preventing seizures and modulating abnormal brain activity.

Uses:

  • Epilepsy:

    • Monotherapy or adjunct therapy for partial-onset seizures

    • Generalized tonic-clonic seizures

    • Seizures associated with Lennox-Gastaut syndrome

  • Migraine Prophylaxis:

    • To prevent migraine headaches, not for acute treatment

  • Off-label Uses (under specialist care):

    • Bipolar disorder

    • Weight management (in combination therapies)

    • Alcohol or substance dependence

Additional information

Product Type

Oral Medication

Form

Solid

Age Range

All ages except children below 2 years

Storage Condition

Store in dry place below 25°C protected from moisture.