Description
Topiramate Tablets IP are widely used antiepileptic medications that help manage various types of seizures and prevent migraine headaches. The drug works by stabilizing nerve activity in the brain through multiple mechanisms. It is typically started at a low dose and gradually increased to reduce side effects.
Mechanism of Action:
Topiramate has a broad-spectrum antiepileptic mechanism. It works by:
- Blocking voltage-dependent sodium channels, stabilizing neuronal membranes
- Enhancing GABA activity (inhibitory neurotransmitter)
- Inhibiting AMPA/kainate receptors (glutamate excitatory pathways)
- Inhibiting carbonic anhydrase (weak effect)
These combined actions reduce neuronal excitability, preventing seizures and modulating abnormal brain activity.
Uses:
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Epilepsy:
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Monotherapy or adjunct therapy for partial-onset seizures
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Generalized tonic-clonic seizures
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Seizures associated with Lennox-Gastaut syndrome
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Migraine Prophylaxis:
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To prevent migraine headaches, not for acute treatment
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Off-label Uses (under specialist care):
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Bipolar disorder
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Weight management (in combination therapies)
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Alcohol or substance dependence
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