Description
Super Trimix Injection is a high-concentration compounded formulation used in the treatment of erectile dysfunction (ED), particularly in cases that are resistant to oral PDE5 inhibitors or standard intracavernosal therapies. It combines three potent vasoactive agents—alprostadil, papaverine, and phentolamine—at elevated concentrations to maximize efficacy and duration of penile erection.
- Prostaglandin E1 (Alprostadil) – 40 mcg/mL: A prostaglandin E1 analog that increases cAMP levels, leading to smooth muscle relaxation and enhanced blood flow to the corpus cavernosum.
- Papaverine Hydrochloride – 60 mg/mL: A non-specific phosphodiesterase inhibitor that promotes vasodilation by increasing intracellular cAMP and cGMP levels.
- Phentolamine Mesylate – 2 mg/mL: An alpha-adrenergic antagonist that blocks sympathetic vasoconstriction, supporting sustained blood flow to erectile tissue.
Mechanism of Action
Super Trimix facilitates erection by acting directly at the corpus cavernosum level:
- Alprostadil increases intracellular cAMP → smooth muscle relaxation
- Papaverine inhibits phosphodiesterase enzymes → increases cGMP and cAMP
- Phentolamine blocks alpha-adrenergic receptors → decreases vasoconstriction
Combined, these effects enhance arterial inflow, reduce venous outflow, and produce a rigid erection usually within 5–15 minutes, independent of sexual stimulation.
