Description
Sildenafil Citrate Tablets IP 50 mg is a prescription oral medication designed to treat erectile dysfunction (ED) in men and, in certain cases, pulmonary arterial hypertension (PAH). This medication works by enhancing blood flow to specific areas of the body, such as the penis, enabling improved sexual performance and vascular function.
Indication:
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Erectile Dysfunction (ED):
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Treats the inability to achieve or maintain a firm erection suitable for sexual activity.
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Effective for men with ED caused by physiological or psychological factors, such as stress or anxiety.
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Pulmonary Arterial Hypertension (PAH) (Off-Label Use):
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Used to lower pulmonary blood pressure by relaxing the blood vessels in the lungs, easing blood flow.
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Mechanism of Action:
Sildenafil Citrate belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.
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For ED, it works by inhibiting the enzyme PDE5, which breaks down cyclic guanosine monophosphate (cGMP). cGMP helps relax smooth muscles in the penis, improving blood flow. Sexual stimulation triggers nitric oxide release, which activates cGMP and facilitates an erection. Sildenafil enhances this natural process, resulting in better erectile function.
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For PAH, Sildenafil relaxes the smooth muscles in the pulmonary arteries, reducing vascular resistance and improving oxygenation.
