Description
Omeprazole pellets are small, free-flowing spherical granules containing the proton pump inhibitor (PPI) omeprazole, used primarily for reducing gastric acid secretion. These pellets are typically enteric-coated to protect the drug from degradation in the acidic environment of the stomach and to ensure release in the intestine.
Mechanism of Action: Omeprazole irreversibly inhibits the H⁺/K⁺-ATPase enzyme system (proton pump) in gastric parietal cells, leading to a significant reduction in stomach acid production.
Formulation: Pellets are usually prepared by layering omeprazole onto inert cores (like sugar spheres) followed by an enteric coating. This coating dissolves at higher intestinal pH (≥5.5–6), enabling targeted drug release.
Uses: Widely used in the treatment of conditions such as:
- Gastroesophageal reflux disease (GERD)
- Peptic ulcer disease
- Zollinger–Ellison syndrome
Advantages of Pellet Form:
- Improved stability of acid-labile omeprazole
- Uniform distribution in GI tract
- Flexible dosing (can be filled into capsules or sachets)
- Reduced risk of dose dumping compared to single-unit dosage forms
Administration: Usually filled into hard gelatin capsules or compressed into tablets. Pellets can sometimes be opened and sprinkled on soft food without crushing.
