Description
Ofloxacin, Metronidazole Benzoate & Simethicone Oral Suspension is a broad-spectrum antibacterial, antiprotozoal, and antiflatulent combination used in the treatment of gastrointestinal infections, particularly those associated with diarrhea, dysentery, and abdominal discomfort due to gas or bloating. This suspension is commonly prescribed for both children and adults suffering from mixed bacterial and protozoal intestinal infections.
The combination targets multiple pathogens responsible for gastrointestinal disturbances, including Gram-negative bacteria, anaerobic organisms, and protozoa, while simethicone works to relieve associated gas-related symptoms. The formulation is palatable and easy to administer, especially in pediatric and geriatric populations.
Mechanism of Action:
- Ofloxacin: Inhibits bacterial DNA gyrase and topoisomerase IV, blocking DNA replication and killing bacteria. It is effective against many Gram-positive and Gram-negative organisms, including E. coli, Salmonella, and Shigella.
- Metronidazole Benzoate: A prodrug converted into active metronidazole in the body, it disrupts DNA synthesis in anaerobic bacteria and protozoa like Entamoeba histolytica and Giardia lamblia.
- Simethicone: Acts by reducing surface tension of gas bubbles in the stomach and intestines, helping to relieve bloating, discomfort, and flatulence by promoting easier gas elimination.
Indications:
- Acute or chronic diarrhea of bacterial or protozoal origin
- Gastroenteritis with gas and bloating
- Amoebiasis and giardiasis
- Traveler’s diarrhea
- Mixed intestinal infections
- Flatulence and abdominal discomfort associated with infection
