Description
Norethisterone (also called norethindrone) is a synthetic progestin used in various gynecological conditions related to hormonal imbalance. It mimics the action of the natural hormone progesterone, helping to regulate the menstrual cycle and manage estrogen effects on the endometrium. It is also used to delay menstruation when needed.
Mechanism of Action:
Norethisterone binds to progesterone receptors in the body and acts primarily on the endometrium. It:
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- Prevents the growth and thickening of the uterine lining
- Inhibits ovulation (at higher doses)
- Alters cervical mucus to make it less favorable for sperm penetration
These effects help in controlling abnormal bleeding and managing cycle-related disorders.
Uses:
Norethisterone 5 mg is prescribed for:
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- Irregular menstrual cycles
- Heavy menstrual bleeding (menorrhagia)
- Painful periods (dysmenorrhea)
- Endometriosis
- Premenstrual syndrome (PMS)
- Delay of menstruation (e.g., for travel or events)
- Hormone replacement therapy (HRT) – as a component
