Description
Losartan Potassium Tablets IP 50 mg is a well-tolerated antihypertensive that works by blocking angiotensin II receptors, leading to vasodilation and reduced blood pressure. It is commonly used for managing hypertension, protecting kidney function in diabetic patients, and reducing cardiovascular risk.
Mechanism of Action:
Losartan blocks the binding of angiotensin II (a potent vasoconstrictor) to its AT1 receptor in blood vessels. This prevents vasoconstriction and aldosterone secretion, leading to:
- Vasodilation (widening of blood vessels)
- Reduced blood pressure
- Decreased sodium and water retention
This action helps in lowering blood pressure, improving blood flow, and reducing strain on the heart and kidneys.
Uses:
Losartan Potassium 50 mg is indicated for:
- Essential hypertension (high blood pressure)
- Hypertension with left ventricular hypertrophy
- Nephropathy in type 2 diabetic patients
- Heart failure (off-label in some cases, or when ACE inhibitors are not tolerated)
