Description
Itraconazole + Ofloxacin + Ornidazole + Clobetasol Propionate Cream is a potent quadruple-action topical formulation combining:
- Itraconazole – a broad-spectrum antifungal targeting dermatophytes and yeasts by disrupting membrane integrity.
- Ofloxacin – a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, effective against gram-positive and gram-negative organisms.
- Ornidazole – an antiprotozoal and antibacterial agent that damages DNA of anaerobes and certain parasites.
- Clobetasol Propionate (0.05%) – a super‑high potency corticosteroid that effectively reduces inflammation, swelling, and itching.
This cream offers broad-spectrum antimicrobial action along with powerful anti-inflammatory relief—ideal for complex or resistant skin infections involving fungus, bacteria, or anaerobes.
Mechanism:
- Clobetasol suppresses the immune response and eases symptoms.
- Itraconazole impedes fungal cell membrane formation.
- Ofloxacin and ornidazole tackle bacterial and protozoal DNA replication.
These combined effects offer wide coverage alongside anti-inflammatory relief
Uses:
Used for mixed infections involving fungi (e.g., ringworm, athlete’s foot), bacteria, and anaerobes, often alongside inflammation. Commonly prescribed in conditions like tinea corporis/cruris, seborrheic dermatitis, and mixed bacterial-fungal dermatitis.
