Description
Amoxicillin and Potassium Clavulanate Tablets IP are a broad-spectrum antibiotic combination used to treat a wide range of bacterial infections. Amoxicillin is a penicillin-class beta-lactam antibiotic that works by inhibiting bacterial cell wall synthesis, leading to bacterial death. However, some bacteria produce beta-lactamase enzymes that make them resistant to amoxicillin alone.
Potassium clavulanate is a beta-lactamase inhibitor that protects amoxicillin from degradation by these enzymes, thereby extending its spectrum of activity to include beta-lactamase–producing organisms. This makes the combination effective against both gram-positive and gram-negative bacteria, including resistant strains.
Mechanism of Action:
- Amoxicillin interferes with bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).
- Clavulanic acid binds irreversibly to beta-lactamase enzymes produced by resistant bacteria, preventing them from inactivating amoxicillin.
Indications:
- Upper respiratory tract infections (e.g., sinusitis, tonsillitis, otitis media)
- Lower respiratory tract infections (e.g., bronchitis, community-acquired pneumonia)
- Urinary tract infections (UTIs)
- Skin and soft tissue infections
- Dental infections
- Bone and joint infections
- Gynecological infections
