Description
Sildenafil Citrate Tablets IP 100 mg is an oral medication widely used to treat erectile dysfunction (ED) in men. It is also prescribed for managing pulmonary arterial hypertension (PAH) under specific circumstances. The medication works by enhancing blood flow to specific areas of the body, primarily the penis, to improve and sustain an erection in response to sexual stimulation.
Indications:
- Treatment for men who experience difficulty achieving or maintaining an erection sufficient for sexual intercourse.
- Sildenafil helps relax blood vessels in the lungs, improving blood flow and reducing the workload on the heart.
Mechanism of Action: Sildenafil Citrate belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.
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For Erectile Dysfunction:
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Sexual stimulation releases nitric oxide in the penile tissues.
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Sildenafil enhances the effect of nitric oxide by inhibiting PDE5, which breaks down cyclic guanosine monophosphate (cGMP).
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This results in smooth muscle relaxation and increased blood flow to the penis, facilitating an erection.
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For PAH:
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Sildenafil relaxes the smooth muscles in the pulmonary arteries, reducing vascular resistance and improving oxygen delivery.
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